Schiff bases of indoline-2,3-dione (isatin) with potential antiproliferative activity
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چکیده
منابع مشابه
Schiff bases of indoline-2,3-dione (isatin) with potential antiproliferative activity
UNLABELLED BACKGROUND Cancer is one of the most dreaded diseases and it is a leading cause of mankind death worldwide. Recent reports documented a remarkable antiproliferative activity of isatin nucleus against various cancer cell lines. The current work describes the antiproliferative activity of Schiff bases of combinatorial mixtures of the isatin derivatives M1-M22 as well as the individu...
متن کاملSchiff bases of indoline-2,3-dione (isatin) derivatives and nalidixic acid carbohydrazide, synthesis, antitubercular activity and pharmacophoric model building.
Tuberculosis (TB) remains among the world's great public health challenges. Worldwide resurgence of TB is due to two major problems: the AIDS epidemic, which started in the mid-1980s, and the outbreak of multidrug resistant (MDR) TB. Thus, there is an urgent need for anti-TB drugs with enhanced activity against MDR strains. In recent years, Schiff bases of 1H-indole-2,3-diones are reported to e...
متن کاملSchiff bases of indoline-2,3-dione: potential novel inhibitors of Mycobacterium tuberculosis (Mtb) DNA gyrase.
In the present study a series of Schiff bases of indoline-2,3-dione were synthesized and investigated for their Mtb gyrase inhibitory activity. Promising inhibitory activity was demonstrated with some of these derivatives, which exhibited IC(50) values ranging from 50-157 mM. The orientation and the ligand-receptor interactions of such molecules within the Mtb DNA gyrase A subunit active site w...
متن کاملAnticonvulsant activity of Schiff bases of isatin derivatives.
Schiff bases of N-methyl and N-acetyl isatin derivatives with different aryl amines have been synthesized and screened for anticonvulsant activities against maximal electroshock (MES) and subcutaneous metrazole (ScMet). N-methyl-5-bromo-3-(p-chlorophenylimino) isatin (2) exhibited anticonvulsant activity in MES and ScMet with LD50 > 600 mg kg(-1), showing better activity than the standard drugs...
متن کاملSynthesis of some isatin Schiff bases in microwave irradiation condition
An efficient and mild methodology for rapid and efficient synthesis of isatin Schiff bases was described under microwave irradiation and solvent free condition.aromatic or heterocyclic Primary amines and isatin could be selectively reacted under microwave irradiation into the corresponding isatin Schiff bases in high yields and short reaction time.
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ژورنال
عنوان ژورنال: Chemistry Central Journal
سال: 2012
ISSN: 1752-153X
DOI: 10.1186/1752-153x-6-49